Hi,

The new version released of Prism updated these Silverlight Quickstarts in order to show the functionality on WPF applications.
Prism 5 has some Quickstart samples that describe a WPF app implemented with MVVM pattern and using more Prism features like Navigation, InteractionRequestNotification and Modularity.

You may find the last Prism release (version 5) in the following link:

• Prism 5.0 for .NET 4.5
  

In order to run the Quickstarts, you would need to Build the Prism Library first. Then, some QuickStarts that may help you would be the following:

• BasicMVVMQuickstart_Desktop
• Interactivity
• UIComposition_Desktop
• View-Switching Navigation_Desktop
  

Based on my understanding, Prism v4 and v5 provide well support for the MVVM pattern on WPF as shown on Silverlight samples. The MVVM pattern would not be quite affected when implemented into these both project types.

I hope this helped you,
Regards.

Gabriel Ostrowsky
https://blogs.southworks.net/gostrowsky