Yes, of course. Unity is fully supported in Prism 5 (and Prism 6 which we expect to release next week for WPF and UWP - http://github.com/PrismLibrary/Prism). And I don't think we introduced any breaking changes in Prism 4 or 5 that would make the StockTrader code from Prism 2.2 stop working.
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